The comprehensiveness of the Qur'an, in the sense of the immortality of the Qur'an at any time and its universality in any place, is one of the basic topics of various topics of Qur'anic sciences. From the past until now, Muslim thinkers have explained this basis by referring to verses and traditions. Accepting the maximalist point of view, some people have considered the appearance of the words of the Qur'an as actual, comprehensive of all human and natural sciences. A group has chosen the theory of moderation and introduced the Qur'an as a guide for man in material and spiritual matters. Some have expressed a minimal point of view and considered the completeness of the Qur'an in terms of values ​​and moral issues. In the meantime, in the Quranic thought of the Supreme Leader, the maximalist view is not valid, and also the minimal view is rejected due to the secularist view of the Quran and abandoning it and accepting part of the verses of the Quran and denying the other part. By accepting the moderate comprehensiveness of the Qur'an, a part of it is in the guidance dimension, the expression of all matters related to the guidance and education of human beings in various aspects, personal, social, spiritual, etc., and another part is in the scientific dimension, the fundamental transformation in human sciences. He knows the meaning of changing the foundations of these sciences from their western origin to the Qur'anic position.